Search results for "Biliary Elimination"
showing 2 items of 2 documents
Oleoylethanolamide restores alcohol-induced inhibition of neuronal proliferation and microglial activity in striatum
2019
Previous findings demonstrate a homeostatic role for oleoylethanolamide (OEA) signaling in the ethanol-related neuroinflammation and behavior. However, extensive research is still required in order to unveil the effects of OEA on a number of neurobiological functions such as adult neurogenesis, cell survival and resident neuroimmunity that become notably altered by alcohol. Daily consumption of ethanol (10%) for 2 weeks (6.3& #x202F;± 1.1 g/kg/day during last 5 days) caused hypolocomotor activity in rats. This effect appears to rely on central signaling mechanisms given that alcohol increased the OEA levels, the gene expression of OEA-synthesizing enzyme Nape-pld and the number of PPARα-imm…
Xenobiotic Metabolism
1999
Publisher Summary This chapter reveals that one's body takes up significant amounts of material that are used neither as energy substrates nor as building blocks for biological matrices. Uptake of such xenobiotica occurs mainly with the food but also by inhalation or transdermally. If these compounds accumulated in the organism, the resulting body burden would have been enormous. Thus, efficient mechanisms for the excretion of such compounds that have their roots very early in the evolution of life have developed. The two major elimination pathways in humans are excretion via bile and excretion via urine. For volatile compounds, exhalation can represent the dominant mechanism of excretion. …